Reliability of TMS motor evoked potentials in quadriceps of subjects with chronic hemiparesis after stroke

Lewis A Wheaton; Federico Villagra; Daniel F Hanley; Richard F Macko; Larry W Forrester

doi:10.1016/j.jns.2008.09.012

Reliability of TMS motor evoked potentials in quadriceps of subjects with chronic hemiparesis after stroke

Lewis A Wheaton, Federico Villagra, Daniel F Hanley, Richard F Macko, Larry W Forrester

Department of Life Sciences

Baltimore Veterans Affairs Medical Centre GRECC

Research output: Contribution to journal › Article › peer-review

37 Citations (Scopus)

Abstract

Transcranial magnetic stimulation (TMS) non-invasively measures excitability of central motor pathways in humans and is used to characterize neuroplasticity after stroke. Using TMS to index lower extremity neuroplasticity after gait rehabilitation requires test-retest reliability. This study assesses the reliability of TMS-derived variables measured at bilateral quadriceps of chronic hemiparetic stroke survivors. Results support using measures of both paretic and nonparetic motor threshold, motor evoked potential (MEP) latencies; and nonparetic MEP amplitudes. Implications for longitudinal research are discussed.

Original language	English
Pages (from-to)	115-117
Number of pages	3
Journal	Journal of the Neurological Sciences
Volume	276
Issue number	1-2
Early online date	22 Oct 2008
DOIs	https://doi.org/10.1016/j.jns.2008.09.012
Publication status	Published - 15 Jan 2009

Keywords

Adult
Aged
Aged, 80 and over
Electric Stimulation
Evoked Potentials, Motor
Female
Gait
Humans
Male
Middle Aged
Paresis
Quadriceps Muscle
Recovery of Function
Reproducibility of Results
Stroke
Transcranial Magnetic Stimulation
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Quadriceps
Lower extremity
Paretic
TMS
Reliability

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title = "Reliability of TMS motor evoked potentials in quadriceps of subjects with chronic hemiparesis after stroke",

abstract = "Transcranial magnetic stimulation (TMS) non-invasively measures excitability of central motor pathways in humans and is used to characterize neuroplasticity after stroke. Using TMS to index lower extremity neuroplasticity after gait rehabilitation requires test-retest reliability. This study assesses the reliability of TMS-derived variables measured at bilateral quadriceps of chronic hemiparetic stroke survivors. Results support using measures of both paretic and nonparetic motor threshold, motor evoked potential (MEP) latencies; and nonparetic MEP amplitudes. Implications for longitudinal research are discussed.",

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author = "Wheaton, {Lewis A} and Federico Villagra and Hanley, {Daniel F} and Macko, {Richard F} and Forrester, {Larry W}",

note = "Funding Information: Grant support: National Institutes of Health, NIA (P60AG 12583) University of Maryland Claude D. Pepper Older Americans Independence Center; the Department of Veterans Affairs and Veterans Affairs Medical Center Baltimore Geriatrics Research, Education and Clinical Center (GRECC), and Rehabilitation Research & Development Exercise and Robotics Center of Excellence (B3390K); NINDS 1RO1 NS 24282-08; the France-Merrick Foundation, the Johns Hopkins GCRC (NCRR #MO1-00052) and the Eleanor Naylor Dana Charitable Trust.",

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language = "English",

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AU - Wheaton, Lewis A

AU - Villagra, Federico

AU - Hanley, Daniel F

AU - Macko, Richard F

AU - Forrester, Larry W

N1 - Funding Information: Grant support: National Institutes of Health, NIA (P60AG 12583) University of Maryland Claude D. Pepper Older Americans Independence Center; the Department of Veterans Affairs and Veterans Affairs Medical Center Baltimore Geriatrics Research, Education and Clinical Center (GRECC), and Rehabilitation Research & Development Exercise and Robotics Center of Excellence (B3390K); NINDS 1RO1 NS 24282-08; the France-Merrick Foundation, the Johns Hopkins GCRC (NCRR #MO1-00052) and the Eleanor Naylor Dana Charitable Trust.

PY - 2009/1/15

Y1 - 2009/1/15

N2 - Transcranial magnetic stimulation (TMS) non-invasively measures excitability of central motor pathways in humans and is used to characterize neuroplasticity after stroke. Using TMS to index lower extremity neuroplasticity after gait rehabilitation requires test-retest reliability. This study assesses the reliability of TMS-derived variables measured at bilateral quadriceps of chronic hemiparetic stroke survivors. Results support using measures of both paretic and nonparetic motor threshold, motor evoked potential (MEP) latencies; and nonparetic MEP amplitudes. Implications for longitudinal research are discussed.

AB - Transcranial magnetic stimulation (TMS) non-invasively measures excitability of central motor pathways in humans and is used to characterize neuroplasticity after stroke. Using TMS to index lower extremity neuroplasticity after gait rehabilitation requires test-retest reliability. This study assesses the reliability of TMS-derived variables measured at bilateral quadriceps of chronic hemiparetic stroke survivors. Results support using measures of both paretic and nonparetic motor threshold, motor evoked potential (MEP) latencies; and nonparetic MEP amplitudes. Implications for longitudinal research are discussed.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Electric Stimulation

KW - Evoked Potentials, Motor

KW - Female

KW - Gait

KW - Humans

KW - Male

KW - Middle Aged

KW - Paresis

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KW - Recovery of Function

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KW - Stroke

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KW - Journal Article

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KW - Research Support, U.S. Gov't, Non-P.H.S.

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KW - Reliability

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ER -

Reliability of TMS motor evoked potentials in quadriceps of subjects with chronic hemiparesis after stroke

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Keywords

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