From blur to optical oasis: Image resolution improvements to speciate parasitic infections

Research output: Chapter in Book/Report/Conference proceedingConference Proceeding (Non-Journal item)

Abstract

Here we describe the evaluation and subsequent re-design of an optical, point of care parasite infection diagnostic instrument. The original optical system was resolution limited by the focusing objective which had an f5.6 numerical aperture with an effective 3Mega pixel performance giving a minimum resolution of 3.73μm. Changing the objective to an f2.4 lens and employing 12Mega pixel sensor, combined with illumination modelling and re-design, improved resolution to 1.46μm within the necessary 3mm field of view. This presents a simple case for change which leads to benefits in both instrument sensitivity and improved parasite identification and speciation.

Original languageEnglish
Title of host publicationFrontiers in Biophotonics and Imaging
EditorsSumeet Mahajan, Stefanie Reichelt
PublisherSPIE
ISBN (Electronic)9781510646025
DOIs
Publication statusPublished - 06 Oct 2021
EventFrontiers in Biophotonics and Imaging 2021 - Glasgow, United Kingdom of Great Britain and Northern Ireland
Duration: 28 Sept 202130 Sept 2021

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
Volume11879
ISSN (Print)0277-786X
ISSN (Electronic)1996-756X

Conference

ConferenceFrontiers in Biophotonics and Imaging 2021
Country/TerritoryUnited Kingdom of Great Britain and Northern Ireland
CityGlasgow
Period28 Sept 202130 Sept 2021

Keywords

  • Diagnostic
  • Imaging
  • Microscopy
  • Optical
  • Parasitology
  • Resolution

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