Research output per year
Research output per year
Personal profile
Research interests
My research focuses on the identification and characterisation of helminth proteins essential to the parasites survival in the host. The aim of this research is to discover novel vaccine candidates/drug targets and to also gain a deeper understanding of host/parasite interactions. Using bioinformatic approaches, my research also examines the evolution of gene families (such as the SmVAL family) across parasitic and non-parasitic species.
Profile
2022-present
Senior Lecturer in Veterinary Biosciences, Department of Life Sciences, Aberstwyth University, UK
2013-2022
Lecturer in Veterinary Biosciences, IBERS, Aberstwyth University, UK
2010-2013
EU-funded Post-Doctoral Research Associate, IBERS, Aberystwyth University, UK
2008-2009
Research Technician, IBERS, Aberystwyth University, UK
2002-2009
Wellcome Trust PhD programme, under supervision of Dr. Karl Hoffmann, Department of Pathology, University of Cambridge, UK
1998-2002
BSc (Hons.) Degree in Immunology, Edinburgh University, UK
Responsibilities
Degree Programme Coordinator BSc Veterinary Bisociences
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
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Profiles
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Chemical modulation of Schistosoma mansoni lysine specific demethylase 1 (SmLSD1) induces wide-scale biological and epigenomic changes
Padalino, G., Celatka, C., Rienhoff Jr., H. Y., Kalin, J. H., Cole, P. A., Lassalle, D., Forde-Thomas, J., Chalmers, I., Brancale, A., Grunau, C. & Hoffmann, K., 30 Mar 2023, In: Wellcome Open Research. 8, 146, 29 p., 146.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)66 Downloads (Pure) -
Protective human IgE responses are promoted by comparable life-cycle dependent Tegument Allergen-Like expression in Schistosoma haematobium and Schistosoma mansoni infection
Oettle, R. C., Dickinson, H. A., Fitzsimmons, C. M., Sacko, M., Tukahebwa, E. M., Chalmers, I. W., Wilson, S. & Loke, P. (ed.), 25 May 2023, In: PLOS Pathogens. 19, 5, 20 p., e1011037.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)119 Downloads (Pure) -
Special considerations for studies of extracellular vesicles from parasitic helminths: A community-led roadmap to increase rigour and reproducibility
White, R., Sotillo, J., Ancarola, M. E., Borup, A., Boysen, A. T., Brindley, P. J., Buzás, E. I., Cavallero, S., Chaiyadet, S., Chalmers, I. W., Cucher, M. A., Dagenais, M., Davis, C. N., Devaney, E., Duque-Correa, M. A., Eichenberger, R. M., Fontenla, S., Gasan, T. A., Hokke, C. H., Kosanovic, M., & 22 others, 05 Jan 2023, In: Journal of Extracellular Vesicles. 12, 1, 16 p., 12298.Research output: Contribution to journal › Article › peer-review
Open AccessFile16 Citations (Scopus)80 Downloads (Pure) -
In silico characterisation of the complete Ly6 protein family in Fasciola gigantica supported through transcriptomics of the newly-excysted juveniles
Davey, S. D., Chalmers, I. W., Fernandez-Fuentes, N., Swain, M. T., Smith, D., Abbas Abidi, S. M., Saifullah, M. K., Raman, M., Ravikumar, G., McVeigh, P., Maule, A. G., Brophy, P. M. & Morphew, R. M., 17 Jan 2022, In: Molecular Omics. 18, 1, p. 45-56 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)73 Downloads (Pure) -
Schistosoma mansoni α-N-acetylgalactosaminidase (SmNAGAL) regulates coordinated parasite movement and egg production
Hulme, B. J., Geyer, K. K., Forde-Thomas, J. E., Padalino, G., Phillips, D. W., Ittiprasert, W., Karinshak, S. E., Mann, V. H., Chalmers, I. W., Brindley, P. J., Hokke, C. H. & Hoffmann, K. F., 13 Jan 2022, In: PLOS Pathogens. 18, 1, 35 p., e1009828.Research output: Contribution to journal › Article › peer-review
Open AccessFile18 Citations (Scopus)129 Downloads (Pure) -
Anti-schistosomal activities of quinoxaline-containing compounds: From hit identification to lead optimisation
Padalino, G., El-Sakkary, N., Liu, L. J., Liu, C., Harte, D. S. G., Barnes, R. E., Sayers, E., Forde-Thomas, J., Whiteland, H., Bassetto, M., Ferla, S., Johnson, G., Jones, A. T., Caffrey, C. R., Chalmers, I., Brancale, A. & Hoffmann, K. F., 15 Dec 2021, In: European Journal of Medicinal Chemistry. 226, 19 p., 113823.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (Scopus)144 Downloads (Pure) -
Schistosoma mansoni venom allergen-like protein 6 (SmVAL6) maintains tegumental barrier function
Perally, S., Geyer, K. K., Farani, P. S. G., Chalmers, I. W., Fernandez-Fuentes, N., Maskell, D. R., Hulme, B. J., Forde-Thomas, J., Phillips, D., Farias, L. P., Collins, J. J. & Hoffmann, K. F., 01 Mar 2021, In: International Journal for Parasitology. 51, 4, p. 251-261 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (Scopus)88 Downloads (Pure) -
Identification of 6-(piperazin-1-yl)-1,3,5-triazine as a chemical scaffold with broad anti-schistosomal activities
Padalino, G., Chalmers, I. W., Brancale, A. & Hoffmann, K. F., 13 Nov 2020, In: Wellcome Open Research. 5, 37 p., 169.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (Scopus)44 Downloads (Pure) -
Erratum to ‘Combining bioinformatics, cheminformatics, functional genomics and whole organism approaches for identifying epigenetic drug targets in Schistosoma mansoni’: [IJP Drugs Drug Resist. 8 (2018) 559–570]
Padalino, G., Ferla, S., Brancale, A., Chalmers, I. & Hoffmann, K., Aug 2019, In: International Journal for Parasitology: Drugs and Drug Resistance. 10, p. 91 1 p.Research output: Contribution to journal › Correction › peer-review
Open AccessFile103 Downloads (Pure) -
Schistosoma mansoni venom allergen-like proteins: Phylogenetic relationships, stage-specific transcription and tissue localization as predictors of immunological cross-reactivity
Farias, L. P., Chalmers, I. W., Perally, S., Rofatto, H. K., Jackson, C. J., Brown, M., Khouri, M. I., Barbosa, M. M. F., Hensbergen, P. J., Hokke, C. H., Leite, L. C. C. & Hoffmann, K. F., 01 Jul 2019, In: International Journal for Parasitology. 49, 8, p. 593-599 7 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile8 Citations (Scopus)177 Downloads (Pure) -
The repositioning of epigenetic probes/inhibitors identifies new anti-schistosomal lead compounds and chemotherapeutic targets
Whatley, K., Padalino, G., Whiteland, H., Geyer, K. K., Hulme, B. J., Chalmers, I., Forde-Thomas, J., Ferla, S., Brancale, A. & Hoffmann, K., 15 Nov 2019, In: PLoS Neglected Tropical Diseases. 13, 11, 24 p., e0007693.Research output: Contribution to journal › Article › peer-review
Open AccessFile20 Citations (Scopus)196 Downloads (Pure)
Datasets
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Chemical modulation of Schistosoma mansoni lysine specific demethylase 1 (SmLSD1) induces wide-scale biological and epigenomic changes - Supplementary tables and movies
Padalino, G., Celatka, C. A., Young Rienhoff Jr, H., Kalin, J. H., Cole, P. A., Lassalle, D., Forde-Thomas, J., Chalmers, I. W., Brancale, A., Grunau, C. & Hoffmann, K. F., figshare, 04 Jan 2023
DOI: 10.6084/m9.figshare.21814623
Dataset
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Identification of 6-(piperazin-1-yl)-1,3,5-triazine as a chemical scaffold with broad anti-schistosomal activities - Underlying data
Padalino, G., Chalmers, I. W., Brancale, A. & Hoffmann, K., figshare, 23 Jun 2020
DOI: 10.6084/m9.figshare.12473108, https://figshare.com/articles/Identification_of_6-_piperazin-1-yl_-1_3_5-triazine_as_a_chemical_scaffold_with_broad_anti-schistosomal_activities/12473108
Dataset
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Chemical modulation of Schistosoma mansoni lysine specific demethylase 1 (SmLSD1) induces wide-scale biological and epigenomic changes - Supplementary Figures
Padalino, G., Celatka, C. A., Young Rienhoff Jr, H., Kalin, J. H., A Cole, P., Lassalle, D., Forde-Thomas, J., Chalmers, I. W., Brancale, A., Grunau, C. & Hoffmann, K. F., figshare, 05 Mar 2023
DOI: 10.6084/m9.figshare.21814710
Dataset
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Identification of 6-(piperazin-1-yl)-1,3,5-triazine as a chemical scaffold with broad anti-schistosomal activities - Extended data
Padalino, G., Chalmers, I. W., Brancale, A. & Hoffmann, K., figshare, 23 Jun 2020
DOI: 10.6084/m9.figshare.12546449, https://figshare.com/articles/Identification_of_6-_piperazin-1-yl_-1_3_5-triazine_as_a_chemical_scaffold_with_broad_anti-schistosomal_activities/12546449/2
Dataset
File
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Parasites: Past or Future
Chalmers, I. (Speaker)
17 Jun 2015Activity: Talk or presentation › Oral presentation
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National Science and Engineering Week
Chalmers, I. (Participant)
17 Apr 2015Activity: Participating in or organising an event › Festival or Exhibition
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Parasites: Past or Future talk
Chalmers, I. (Speaker)
17 Jun 2014Activity: Talk or presentation › Oral presentation
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National Science Engineering Week
Chalmers, I. (Participant)
16 Apr 2014Activity: Participating in or organising an event › Festival or Exhibition
Prizes
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Queen’s Anniversary Prize 2023
Brophy, P. (Recipient), Hamilton, J. (Recipient), Hoffmann, K. (Recipient), Jones, R. (Recipient), Chalmers, I. (Recipient), Morphew, R. (Recipient), Rinaldi, G. (Recipient), Williams, H. (Recipient) & Barber, I. (Recipient), 2023
Prize: Prize (including medals and awards)