Allbwn Ymchwil fesul blwyddyn
Allbwn Ymchwil fesul blwyddyn
Proffil personol
Diddordebau ymchwil
My research focuses on the identification and characterisation of helminth proteins essential to the parasites survival in the host. The aim of this research is to discover novel vaccine candidates/drug targets and to also gain a deeper understanding of host/parasite interactions. Using bioinformatic approaches, my research also examines the evolution of gene families (such as the SmVAL family) across parasitic and non-parasitic species.
Proffil
2022-present
Senior Lecturer in Veterinary Biosciences, Department of Life Sciences, Aberstwyth University, UK
2013-2022
Lecturer in Veterinary Biosciences, IBERS, Aberstwyth University, UK
2010-2013
EU-funded Post-Doctoral Research Associate, IBERS, Aberystwyth University, UK
2008-2009
Research Technician, IBERS, Aberystwyth University, UK
2002-2009
Wellcome Trust PhD programme, under supervision of Dr. Karl Hoffmann, Department of Pathology, University of Cambridge, UK
1998-2002
BSc (Hons.) Degree in Immunology, Edinburgh University, UK
Cyfrifoldebau
Degree Programme Coordinator BSc Veterinary Bisociences
Arbenigedd sy’n gysylltiedig â NDC y CU
Yn 2015, cytunodd gwladwriaethau sy’n aelodau'r Cenhedloedd Unedig ar 17 o Nodau Datblygu Cynaliadwy (NDC) byd-eang i ddod â thlodi i ben, diogelu’r blaned a sicrhau ffyniant i bawb. Mae gwaith y person hwn yn cyfrannu at y NDC canlynol:
Ôl bys
Ewch i ganol y pynciau ymchwil lle mae Iain Chalmers ar waith. Mae’r labelau pwnc hyn yn dod o waith y person hwn. Gyda’i gilydd maen nhw’n ffurfio ôl bys unigryw.
- 1 Proffiliau Tebyg
Cydweithrediadau a’r prif feysydd ymchwil yn ystod y pum mlynedd ddiwethaf
Cydweithrediad allanol yn ddiweddar ar lefel gwlad/tiriogaeth. Plymiwch i mewn i'r manylion drwy glicio ar y dotiau neu
Proffiliau
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Chemical modulation of Schistosoma mansoni lysine specific demethylase 1 (SmLSD1) induces wide-scale biological and epigenomic changes
Padalino, G., Celatka, C., Rienhoff Jr., H. Y., Kalin, J. H., Cole, P. A., Lassalle, D., Forde-Thomas, J., Chalmers, I., Brancale, A., Grunau, C. & Hoffmann, K., 30 Maw 2023, Yn: Wellcome Open Research. 8, 146, 29 t., 146.Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
Mynediad agoredFfeil1 Dyfyniad (Scopus)66 Wedi eu Llwytho i Lawr (Pure) -
Protective human IgE responses are promoted by comparable life-cycle dependent Tegument Allergen-Like expression in Schistosoma haematobium and Schistosoma mansoni infection
Oettle, R. C., Dickinson, H. A., Fitzsimmons, C. M., Sacko, M., Tukahebwa, E. M., Chalmers, I. W., Wilson, S. & Loke, P. (gol.), 25 Mai 2023, Yn: PLOS Pathogens. 19, 5, 20 t., e1011037.Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
Mynediad agoredFfeil1 Dyfyniad (Scopus)119 Wedi eu Llwytho i Lawr (Pure) -
Special considerations for studies of extracellular vesicles from parasitic helminths: A community-led roadmap to increase rigour and reproducibility
White, R., Sotillo, J., Ancarola, M. E., Borup, A., Boysen, A. T., Brindley, P. J., Buzás, E. I., Cavallero, S., Chaiyadet, S., Chalmers, I. W., Cucher, M. A., Dagenais, M., Davis, C. N., Devaney, E., Duque-Correa, M. A., Eichenberger, R. M., Fontenla, S., Gasan, T. A., Hokke, C. H., Kosanovic, M., & 22 eraill, 05 Ion 2023, Yn: Journal of Extracellular Vesicles. 12, 1, 16 t., 12298.Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
Mynediad agoredFfeil16 Dyfyniadau (Scopus)80 Wedi eu Llwytho i Lawr (Pure) -
In silico characterisation of the complete Ly6 protein family in Fasciola gigantica supported through transcriptomics of the newly-excysted juveniles
Davey, S. D., Chalmers, I. W., Fernandez-Fuentes, N., Swain, M. T., Smith, D., Abbas Abidi, S. M., Saifullah, M. K., Raman, M., Ravikumar, G., McVeigh, P., Maule, A. G., Brophy, P. M. & Morphew, R. M., 17 Ion 2022, Yn: Molecular Omics. 18, 1, t. 45-56 12 t.Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
Mynediad agoredFfeil3 Dyfyniadau (Scopus)73 Wedi eu Llwytho i Lawr (Pure) -
Schistosoma mansoni α-N-acetylgalactosaminidase (SmNAGAL) regulates coordinated parasite movement and egg production
Hulme, B. J., Geyer, K. K., Forde-Thomas, J. E., Padalino, G., Phillips, D. W., Ittiprasert, W., Karinshak, S. E., Mann, V. H., Chalmers, I. W., Brindley, P. J., Hokke, C. H. & Hoffmann, K. F., 13 Ion 2022, Yn: PLOS Pathogens. 18, 1, 35 t., e1009828.Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
Mynediad agoredFfeil18 Dyfyniadau (Scopus)129 Wedi eu Llwytho i Lawr (Pure) -
Anti-schistosomal activities of quinoxaline-containing compounds: From hit identification to lead optimisation
Padalino, G., El-Sakkary, N., Liu, L. J., Liu, C., Harte, D. S. G., Barnes, R. E., Sayers, E., Forde-Thomas, J., Whiteland, H., Bassetto, M., Ferla, S., Johnson, G., Jones, A. T., Caffrey, C. R., Chalmers, I., Brancale, A. & Hoffmann, K. F., 15 Rhag 2021, Yn: European Journal of Medicinal Chemistry. 226, 19 t., 113823.Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
Mynediad agoredFfeil7 Dyfyniadau (Scopus)144 Wedi eu Llwytho i Lawr (Pure) -
Schistosoma mansoni venom allergen-like protein 6 (SmVAL6) maintains tegumental barrier function
Perally, S., Geyer, K. K., Farani, P. S. G., Chalmers, I. W., Fernandez-Fuentes, N., Maskell, D. R., Hulme, B. J., Forde-Thomas, J., Phillips, D., Farias, L. P., Collins, J. J. & Hoffmann, K. F., 01 Maw 2021, Yn: International Journal for Parasitology. 51, 4, t. 251-261 11 t.Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
Mynediad agoredFfeil6 Dyfyniadau (Scopus)88 Wedi eu Llwytho i Lawr (Pure) -
Identification of 6-(piperazin-1-yl)-1,3,5-triazine as a chemical scaffold with broad anti-schistosomal activities
Padalino, G., Chalmers, I. W., Brancale, A. & Hoffmann, K. F., 13 Tach 2020, Yn: Wellcome Open Research. 5, 37 t., 169.Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
Mynediad agoredFfeil6 Dyfyniadau (Scopus)44 Wedi eu Llwytho i Lawr (Pure) -
Erratum to ‘Combining bioinformatics, cheminformatics, functional genomics and whole organism approaches for identifying epigenetic drug targets in Schistosoma mansoni’: [IJP Drugs Drug Resist. 8 (2018) 559–570]
Padalino, G., Ferla, S., Brancale, A., Chalmers, I. & Hoffmann, K., Awst 2019, Yn: International Journal for Parasitology: Drugs and Drug Resistance. 10, t. 91 1 t.Allbwn ymchwil: Cyfraniad at gyfnodolyn › Cywiriad › adolygiad gan gymheiriaid
Mynediad agoredFfeil103 Wedi eu Llwytho i Lawr (Pure) -
Schistosoma mansoni venom allergen-like proteins: Phylogenetic relationships, stage-specific transcription and tissue localization as predictors of immunological cross-reactivity
Farias, L. P., Chalmers, I. W., Perally, S., Rofatto, H. K., Jackson, C. J., Brown, M., Khouri, M. I., Barbosa, M. M. F., Hensbergen, P. J., Hokke, C. H., Leite, L. C. C. & Hoffmann, K. F., 01 Gorff 2019, Yn: International Journal for Parasitology. 49, 8, t. 593-599 7 t.Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
Mynediad agoredFfeil8 Dyfyniadau (Scopus)177 Wedi eu Llwytho i Lawr (Pure) -
The repositioning of epigenetic probes/inhibitors identifies new anti-schistosomal lead compounds and chemotherapeutic targets
Whatley, K., Padalino, G., Whiteland, H., Geyer, K. K., Hulme, B. J., Chalmers, I., Forde-Thomas, J., Ferla, S., Brancale, A. & Hoffmann, K., 15 Tach 2019, Yn: PLoS Neglected Tropical Diseases. 13, 11, 24 t., e0007693.Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid
Mynediad agoredFfeil20 Dyfyniadau (Scopus)196 Wedi eu Llwytho i Lawr (Pure)
Setiau Data Ymchwil
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Chemical modulation of Schistosoma mansoni lysine specific demethylase 1 (SmLSD1) induces wide-scale biological and epigenomic changes - Supplementary tables and movies
Padalino, G., Celatka, C. A., Young Rienhoff Jr, H., Kalin, J. H., Cole, P. A., Lassalle, D., Forde-Thomas, J., Chalmers, I. W., Brancale, A., Grunau, C. & Hoffmann, K. F., figshare, 04 Ion 2023
Dangosydd eitem ddigidol (DOI): 10.6084/m9.figshare.21814623
Set ddata
Ffeil -
Identification of 6-(piperazin-1-yl)-1,3,5-triazine as a chemical scaffold with broad anti-schistosomal activities - Underlying data
Padalino, G., Chalmers, I. W., Brancale, A. & Hoffmann, K., figshare, 23 Meh 2020
Dangosydd eitem ddigidol (DOI): 10.6084/m9.figshare.12473108, https://figshare.com/articles/Identification_of_6-_piperazin-1-yl_-1_3_5-triazine_as_a_chemical_scaffold_with_broad_anti-schistosomal_activities/12473108
Set ddata
Ffeil -
Identification of 6-(piperazin-1-yl)-1,3,5-triazine as a chemical scaffold with broad anti-schistosomal activities - Extended data
Padalino, G., Chalmers, I. W., Brancale, A. & Hoffmann, K., figshare, 23 Meh 2020
Dangosydd eitem ddigidol (DOI): 10.6084/m9.figshare.12546449, https://figshare.com/articles/Identification_of_6-_piperazin-1-yl_-1_3_5-triazine_as_a_chemical_scaffold_with_broad_anti-schistosomal_activities/12546449/2
Set ddata
Ffeil -
Chemical modulation of Schistosoma mansoni lysine specific demethylase 1 (SmLSD1) induces wide-scale biological and epigenomic changes - Supplementary Figures
Padalino, G., Celatka, C. A., Young Rienhoff Jr, H., Kalin, J. H., A Cole, P., Lassalle, D., Forde-Thomas, J., Chalmers, I. W., Brancale, A., Grunau, C. & Hoffmann, K. F., figshare, 05 Maw 2023
Dangosydd eitem ddigidol (DOI): 10.6084/m9.figshare.21814710
Set ddata
Ffeil
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Parasites: Past or Future
Chalmers, I. (Siaradwr)
17 Meh 2015Gweithgaredd: Sgwrs neu gyflwyniad › Cyflwyniad llafar
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National Science and Engineering Week
Chalmers, I. (Cyfranogwr)
17 Ebr 2015Gweithgaredd: Cymryd rhan mewn digwyddiad neu drefnu digwyddiad › Ŵyl neu Arddangosfa
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Parasites: Past or Future talk
Chalmers, I. (Siaradwr)
17 Meh 2014Gweithgaredd: Sgwrs neu gyflwyniad › Cyflwyniad llafar
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National Science Engineering Week
Chalmers, I. (Cyfranogwr)
16 Ebr 2014Gweithgaredd: Cymryd rhan mewn digwyddiad neu drefnu digwyddiad › Ŵyl neu Arddangosfa
Gwobrau
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Queen’s Anniversary Prize 2023
Brophy, P. (Derbynydd), Hamilton, J. (Derbynydd), Hoffmann, K. (Derbynydd), Jones, R. (Derbynydd), Chalmers, I. (Derbynydd), Morphew, R. (Derbynydd), Rinaldi, G. (Derbynydd), Williams, H. (Derbynydd) & Barber, I. (Derbynydd), 2023
Gwobr: Gwobr (gan gynnwys medalau a gwobrau)